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Brown fat can reduce obesity through the dissipation of calories as heat.Control of thermogenic gene expression occurs via the induction of various co-activators,most notably PGC-1α.In contrast, the t
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Brown fat can reduce obesity through the dissipation of calories as heat.Control of thermogenic gene expression occurs via the induction of various co-activators,most notably PGC-1α.In contrast, the transcription factor partner(s) of these co-factors are poorly described.We recently have identified interferon regulatory factor 4 (IRF4) serves as a key molecular node in virtually all of the metabolic actions of adipose tissue.Specifically, we have demonstrated that IRF4 regulates lipolysis and lipogenesis in white and brown adipocytes, thermogenesis in brown adipocytes, and M2 polarization in adipose-resident macrophages.Here we demonstrate that IRF4can coordinate PGC-1α to manipulate thermogenesis in BAT.First, we found that IRF4 can interact with PGC-1α, by employing Co-IP and GST-pull down assays.
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