Anti-breast cancer activity of a recombinant telomerase inhibitorPinX1

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：shaoping6868

【摘要】

：

【作者】

：

孙琳陈格郑东燕陈光明魏万国李力石毅

【机构】

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Shanghai Advanced ResearchInstitute, Chinese Academy of Sciences

【出处】

：

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

【发表日期】

：

2014年3期

【关键词】

：

telomerase inhibitor PinX1 breast cancer apoptosis

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Significantly increased levels of telomerase expression and activity have been observed innearly 90％ of the cancer cells,making it a potential target for anti-cancer drugs.Servalanti-tumor drugs targeting telomere and telomerase such as GRN163L were developedand enter into clinical trials (phase Ⅰ/Ⅱ), but there are some disadvantages such as low specifyand high toxicity in small molecule drugs, protein drugs become a novel way to antitumorsbecause of their high specificity and low toxicity.

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Anti-breast cancer activity of a recombinant telomerase inhibitorPinX1

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