【摘 要】
：
Besides hypotheses that cancer stem cells (CSCs), representing a rare population of cancer cells exhibiting stem cell features such as self-renewal, differentiation, tissue regeneration and drug resis
【机 构】
：
Tumor Immunology AG Stem Cells, Institute of Immunology University of Witten / Herdecke Germany
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
Besides hypotheses that cancer stem cells (CSCs), representing a rare population of cancer cells exhibiting stem cell features such as self-renewal, differentiation, tissue regeneration and drug resistance, may originate from adult stem cells or committed progenitor cells it is also assumed that the fusion between stem cells and somatic cells and cancer cells, respectively, could give rise to a CSC phenotype.To investigate for the fusogenic potential of human breast stem cells and human breast cancer cells we co-cultured human M13SV1-EGF-Neo breast stem cells with HS578T-Hyg and MDA-MB-435-Hyg, respectively, human breast cancer cells.After 24h, cells were cultured under selective conditions (+ G418, + Hyg) and cell clones emerged from spontaneous fusion events were isolated and cultivated separately.Short tandem repeat (STR) analysis of hybrid cells showed an overlap of the parental alleles indicating that hybrid cells have been originated from real cell fusion events.
其他文献
When a patients health care team determines that the cancer can no longer be controlled, medical testing and cancer treatment often stop.But the patients care continues.The care focuses on making the
Cancer is a leading health problem for elderly persons in Taiwan.Women of old age, whose opinions towards physical health are influenced by traditional values and cultural background.This study aimed
Phytonutrients such as carotenoids, polyphenols and isothiocyanates were found by us to inhibit sex steroid signaling, the major risk factor for breast cancer.However, estrogens are beneficial for bon
There has been an increase in the life span of cancer patients, thanks to the advances in diagnostic tools and treatment modalities.Most of these patients gain functional capacity and return to their
The lecture will demonstrate the collaboration and motivation of the interdisciplinary team members in making a dream come true and redefining the notion of successful palliative treatment.Our present
Ovarian cancer is the fifth most common cause of death from cancer in women.The standard first-line treatment is a combination of paclitaxel and carboplatin (DDP) or carboplatin alone.In the case of p
Discrepancy between the in-vivo and in-vitro drug sensitivity patterns of human turnout cells has been reported many times.It is often observed that drug screening tests show major differences in in-v
Ribosome-inactivating proteins such as ricin and Shiga-Like Toxin 1 (SLT-1) are highly effective at killing eukaryotic cells.Such molecules can be redirected to kill diseased cells by altering their r
The aim of the present study was to determine whether herpes simplex virus-1 (HSV-1) can be made prostate-specific and oncolytic by either co-infecting an amplicon containing a probasin-derived promot
The field of microRNA (miRNA) represents a new dimension to global regulatory networks that is important for cell development, differentiation and physiology.miRNAs are highly conserved small non-codi