Background The use oftitanium during maxillofacial fixation is limited due to its palpability, mutagenic effects and interference with imaging, which lead to the requirement for subsequent removal.The use of a biologically absorbable fixation material will potentially eliminate these limitations.In this meta-analysis, we analyzed the complications of absorbable fixation in maxillofaciul surgery.Methods: We performed a systematic search of PubMed, Embase, Cochrane Central Register of Systematic Reviews and Cochrane Central Register of Controlled Trials for trials published, through December 2012.Data extracted from literature were analyzed with Review manager 5.0.24.Results: Relevant data was extracted from 20 studies (1673 participants) and revealed that patients in the absorbable group had signi?cantly more complications than those in the titanium group (RR =1.20;95% CI: 1.02-1.42; P =0.03) in all enrolled maxillofacial surgeries.For bimaxillary operation subgroup, the absorbable fixation group did not have a significant increase in complications when compared with the titanium group (RR =1.89; 95% CI: 0.85-4.22; P =0.12).There was no signi?cant difference observed between the absorbable and titanium groups receiving a bilateral sagittal split ramus osteotomy (BSSRO) (RR =1.45; 95% CI: 0.84-2.48; P =0.18) and Le Fort I osteotomy (RR =0.65; 95%CI: 0.34-1.23; P =0.18).The combined results of the five trials revealed that the absorbable group had a significantly lower rate of complications compared to the titanium group (RR =0.71; 95% CI: 0.52-0.97; P =0.03) in fracture fixation.Conclusion: This meta-analysis shows that absorbable fixation systems used for fixation in maxillofacial surgery do not have adequate safety profiles.Subgroup indicated the safety of absorbable fixation systems was superior during fracture fixation.The absorbable fixation systems tend to have a similar favorable safety profile as titanium fixation during Le Fort I, bimaxillary operation and BSSRO.