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  5. Mechanism underlying the inhibitory effect of apelin-13 on glucose deprivation-induced autophagy in

Mechanism underlying the inhibitory effect of apelin-13 on glucose deprivation-induced autophagy in

来源 :第11届中国介入心脏病学大会 | 被引量 : 0次 | 上传用户：tianlanzhijian
【摘 要】
：
Background Low levels of autophagy plays a protective role in cardiomyoctyes, whereas high levels or chronic autophagy can facilitate cell injury and result in the death of cells that cannot be repair
【作 者】
：
JIAO Hui ZHANG Zhi MA Qing-hua FU Wei 
【机 构】
：
Third Affilated Hospital of Liaoning Medical University
【出 处】
：
第11届中国介入心脏病学大会
【发表日期】
：
2013年7期
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Background Low levels of autophagy plays a protective role in cardiomyoctyes, whereas high levels or chronic autophagy can facilitate cell injury and result in the death of cells that cannot be repaired.How to effectively inhibit autophagy and attenuate myocardial damage has become a cardiovascular disease research hotspot.Apelin is highly expressed in the cardiovascular system where it exerts protective effects.The objective of this study is to investigate the effect of apelin-13 on cardiomyocyte autophagy and to determine the underlying mechanism of this effect.
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