Objective: To investigate the clinical features and prognosis of multiple primary colorectal carcinoma (MPCC).Methods: Among 1462 patients with colorectal cancer admitted to our department from January 2000 to December 2007, 39 patients with MPCC were identified based on the Warran and Gates MPC diagnosis criteria.Age of onset, 5 years of survival rate, lesion location and therapeutic method were analyzed retrospectively.Results: (1) The incidence of MPCC was 2.67% (39/1462).18 cases of them were patients with synchronous carcinomas (SC) and 21 cases were diagnosed as metachronous carcinomas(MC).(2) Most tumors were located in the left colon and rectum.The average age of onset were (61.02±13.94) ,and the overall 5-year survival rate was 61.76%.Patients presented with metachronous carcinomas had a better prognosis than those with synchronous carcinomas.(3) The 5-year survival rate of 3 early staged cases as TNM stages I was 100% after radical surgery.30 advanced cases underwent radical surgery combined with adjuvant chemotherapy, the 1-, 3-and 5-year survival rates of which were 93.33%, 83.33%, 73.33% respectively.The 1-, 3-year survival rate of 3 advanced cases who underwent palliative surgery and adjuvant chemotherapy were 66.67% and 0.The 1-, 3-year survival rate of the other 3 advanced cases who underwent palliative chemotherapy were 66.67% and 0.Conclusion: Early diagnosis and effective treatment can help to prolong the survival span of MPC patients.Surgery, chemotherapy is beneficial to the patients with advanced MPCC in improving survival and prognosis.