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Background: The white spotted bamboo shark (Chiloscyllium plagiosum) is an economically important cartilaginous fish and marine animal model for liver regeneration.However, the molecular mechanisms underlying liver regeneration in cartilaginous fish remain unclear because of limited information on the white spotted bamboo shark genome.This study aims to characterize the shark normal liver transcriptome and to identify the differentially expressed transcripts at 3 h after 70%hepatectomy using Illumina-Solexa sequencing.