【摘 要】
：
Pyrrole,as an important heterocycle,broadly exists in agrochemicals,natural products,synthetic intermediates and functional materials,ranging from compounds
【机 构】
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SchoolofPharmacy,LanzhouUniversity,Lanzhou730000
【出 处】
：
中国化学会第十三届全国有机合成化学学术研讨会
论文部分内容阅读
Pyrrole,as an important heterocycle,broadly exists in agrochemicals,natural products,synthetic intermediates and functional materials,ranging from compounds like heme and chlorophyll in life,cholesterol-lowering agent atorvastatin and anticancer drug candidate tallimustine,to its ever-increasing relevance in materials science.Therefore,after its first isolation from bone pyrolysis in 1857,pyrrole has become one of the most prevalent structural units used by chemists for new functional molecule development,which stimulates the development of synthetic methodologies toward the construction of such a key motif.However,it is also known that there is a great need of related methods using very basic chemicals,which would very likely be more atom-economic and environmentally benign.Based on our previous research results,an novel nucleophilic addition/cyclization/aromatization cascade of aromatic alkenes/alkynes,trimethylsilyl cyanide and N,N-disubstituted formamide has been developed to give an efficient method for the synthesis of multisubstituted pyrroles.
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