Objective: Nogo-A is a member of the reticulon family, enriched in the central ner vous system (CNS), its extracellular domain Nogo-66 has a growth inhibitory activity that is specific for neurons, mediated via the receptor (NgR), most of its functions are still not clear.Whether Nogo-A actually modulates the migration and invasion of glioblastoma cell line and what kinds of factors are had an effect on Nogo-A were investigated.