2. 您的位置
3. 首页
4. 会议论文
5. The Critical role of plekstrin-2 in the pathogenesis of JAKV617F-induced myeloproliferative neoplasm

The Critical role of plekstrin-2 in the pathogenesis of JAKV617F-induced myeloproliferative neoplasm

来源 :The 2nd International Symposium on Erythrocyte Biology(2016第 | 被引量 : 0次 | 上传用户：zhizu81748

【摘 要】

：

V617F driver mutation of JAK2 is the leading cause of Philadelphia-chromosome negative myeloproliferative neoplasms (MPNs).Studies on the pathogenesis of JAK2V617F positive MPNs have primarily focused

【作 者】

：

Peng Ji 

【机 构】

：

Northwestern University, Department of Pathology, Chicago, IL 60611

【出 处】

：

The 2nd International Symposium on Erythrocyte Biology(2016第

【发表日期】

：

2016年10期

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　V617F driver mutation of JAK2 is the leading cause of Philadelphia-chromosome negative myeloproliferative neoplasms (MPNs).Studies on the pathogenesis of JAK2V617F positive MPNs have primarily focused on the deregulated JAK2 and STAT activities.

其他文献

Adrenergic Modulation of Glial Activity during Noxious Information Process-ing in Cerebellum

会议

Histone deacetylase 1 as a master regulator for erythroid differentiation

My lab is interested in studying the epigenetic factors which control erythropoiesis.The key regulators,such as antagonistic regulators GATA-1 and PU.1,are responsible for the commitment and different

会议

Calcium Signaling Involvement in Cadmium-Induced Astrocyte Cytotoxicity and Cell Death through Activ

会议

Aberrant DNA binding by mutant (E339D) KLF1 induces upregulation of embryonic-globin in adult mice

The KLF1 transcription factor regulates nearly all aspects of erythroid differentiation including heme synthesis and globin regulation.Previously,in collaborative studies with Dr.James Bieker (New Yor

会议

Induction of γ-Globin Gene Expression via Direct Delivery of Synthetic Zinc Finger DNA-Binding Domai

Reactivation of γ-globin expression has been shown to ameliorate disease phenotypes associated with mutations in the adult β-globin gene,including sickle cell disease.Previous studies have shown that

会议

Pomalidomide reverses gamma-globin silencing during human erythropoiesis through the transcriptional

Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin.Pomalidomide,a third-generation immunomodulatory drug,was proposed to induce fetal hemoglobin productio

会议

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expr

Iron overload results in significant morbidity and mortality in β-thalassemic patients.Insufficient hepcidin is implicated in parenchymal iron overload in β-thalassemia and approaches to increase hepc

会议

β-thalassemiairon overloadhepcidinBMP-Smad signaling

Modeling too much or too little erythropoiesis in mouse disease models

Erythropoietin (Epo) plays a critical role in the regulation of red cell mass (RCM) according to tissue oxygen levels.Hypoxia inducible factor-2 (HIF-2) is known to be a master regulator for Epo expre

会议

Chromatin signaling in transcription and erythropoiesis

The modulation of chromatin structure is a key step in transcription regulation in mammalian cells that eventually determines lineage commitment and differentiation,but the epigenetic regulators that

会议

Translational Hematology: the role of ribosomes in bone marrow failure

More than a decade has passed since the initial identification of ribosomal protein gene mutations in patients with Diamond-Blackfan anemia (DBA),a hematologic disorder that became the founding member

会议