【摘 要】
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Type 2 helper T cells (TH2) are critically involved in allergies and asthma.Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in TH2 cells.ECM1 deficie
【机 构】
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Lab of Molecular Virology Unit Institute Pasteur of Shanghai, Chinese Academy of Sciences Shanghai,
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Type 2 helper T cells (TH2) are critically involved in allergies and asthma.Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in TH2 cells.ECM1 deficiency caused impaired TH2 responses and reduced allergic airway inflammation in vivo.Functional analysis demonstrated that although the TH2 polarization of ECM 1-deficient cells was unimpaired, these cells had a defect in migration and were retained in peripheral lymphoid organs.This was associated with reduced expression of KLF2 and S1P1.We also found that ECM1 could directly bind the interleukin-2 (IL-2) receptor to inhibit IL-2 signaling and activate S1P1 expression.Our data identify a previously unknown function of ECM1 in regulating TH2 cell migration through control of KLF2 and S1P1.
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