【摘 要】
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Objective To observe the efficacy of glucocorticoid and mouse nerve growth factor in the treatment of optic neuritis.Methods 48 patients (48 eyes)with optic neuritis were enrolled in this study.There
【机 构】
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Sichuan suining city central hospital,suining, 629000
【出 处】
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江苏省第十五次眼科学学术会议暨2014中国眼底病论坛——眼底血管疾病诊断治疗进展专题研讨会
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Objective To observe the efficacy of glucocorticoid and mouse nerve growth factor in the treatment of optic neuritis.Methods 48 patients (48 eyes)with optic neuritis were enrolled in this study.There were 8 patients (8 eyes)with optic nerve papillitis,40 patients (40 eyes)with retrobulbar neuritis.The patients were divided into treatment and control group : 22 patients (22 eyes)in the treatment group, and 26 patients (26 eyes)in the control group.The treatment group received intramuscular injection of 30 μg mouse nerve growth factor per day,14 times for one course;Systemic intravenous injection of 15 dexamethasone mg per day for one week,then prednisolone 60 mg per day orally,the dosage was reduced every 7 days for 10 mg; intramuscular injection of vitamin Bl(100 mg )and vitamin B12(0.5 mg)one time per day,use of energy mixture, DibazoI.Control group underwent the same therapy as the treatment group without mouse nerve growth factor.The efficacy differences between two groups were comparatively analyzed.Results Among 22 eyes in the treatment group,18 eyes (81.8%)were markedly effective,two eyes (9.lqo)were valid and two eyes (9.1%)were invalid.The total effective rate was 90.go-/o.Among 26 eyes in the control group,14 eyes (53.8%)were markedly effective,8 eyes(30.8%)were valid and four eyes (15.4%)were invalid.The total effective rate was 84.6 %.The difference of total effective rate between two groups was not statistically significant(x2=0.432,P=0.511 > 0.05); but there was a difference in markedly effective rate between two groups(x2=4.196,P=0.041 < 0.05).Conclusion Mouse nerve growth factor combined with glucocorticoids was effective in the treatment of optic neuritis.
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