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Neuromedin U (NMU) has recently been reported to play a role in nociception.However, to date, the relevant mechanisms still remain unknown.In the present study, we investigated the expression profile of NMU receptors in mouse dorsal root ganglia (DRG) and identified a novel functional role of NMU in modulating T-type Ca2+ channel currents (T-currents) as well as membrane excitability in small DRG neurons.We found that NMU inhibited T-currents in a dose-dependent manner in mouse small DRG neurons that endogenously expressed NMU type 1 (NMUR1), but not NMUR2 receptors.