2. 您的位置
3. 首页
4. 会议论文
5. Hydrogen sulfide attenuates diabetic cardiomyopathy by normalizing ET-NOX-PKCε pathway in streptozot

Hydrogen sulfide attenuates diabetic cardiomyopathy by normalizing ET-NOX-PKCε pathway in streptozot

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：yijiezhented

【摘 要】

：

Aim: Hydrogen sulfide (H2S) plays important roles in mammalian cardiovascular system.The study was to investigate whether NaH S, a donor of H2S, can improve diabetic cardiomyopathy through suppressing

【作 者】

：

Yu-si CHENG Dezai DAI Yin DAI Bi-cheng LIU 

【机 构】

：

School of Medicine, Southeast University, Nanjing 210009, China

【出 处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

diabetic cardiomyopathy ETAR NADPH oxidase PKCε 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Aim: Hydrogen sulfide (H2S) plays important roles in mammalian cardiovascular system.The study was to investigate whether NaH S, a donor of H2S, can improve diabetic cardiomyopathy through suppressing pro-inflammatory biomarkers such as endothelin A receptor (ETAR), NADPH oxidase (NOX) and protein kinase Cε(PKCε).

其他文献

Methylglyoxal, an endogenous aldehyde formed in diabetes, induces nociception by activation of perip

Aim: Methylglyoxal (MG), an endogenous aldehyde formed in the glycolytic pathway, is markedly increased in diabetes states and has been suggested to be involved in diabetic pain.The present examined w

会议

MethylglyoxalTRIPA1 receptorsD-argininediabetic pain

Protective effect of sequoyitol on renal injury in type 2 diabetic rats and the potential mechanisms

Aim: To observe the protective effect of sequoyitol on renal injury in type 2 diabetic rats and to explore their conceivable mechanisms.Methods: Type 2 diabetic rats model was established by intraperi

会议

sequoyitoltype 2 diabeticdiabetic nephropathyoxidative stress

Endothelin-converting enzyme-1 regulates the re-sensitisation of signalling by the glucagon-like pep

Aim: Endothelin-converting enzyme-1 (ECE-1) may regulate trafficking of internalized GPCRs by degrading peptide ligands in endosomes.We examined the impact of ECE-1 on re-sensitisation of the glucagon

会议

GLP-1ECE-1receptor trafficking

The effect of noradrenaline and α1-adrenoceptors antagonists on the rat hepatic stellate cells

Aim: To investigate the distribution and function of α1-adenoreceptor subtypes (α1-AR) in rat hepatic stellate cells (HSC-T6), and to investigate the effect of noradrenaline (NA) on the activation and

会议

hepatic stellate cellsnoradrenalineα1-adrenoceptorshepatic fibrosis

Oxidative stress contributes to cardiac dysfunction in type 1 diabetic mice with myocardial infarcti

Aim: Our previous study showed that an impaired sonic hedgehog (Shh) pathway contributed to cardiac dysfunction in diabetic mice with myocardial infarction (MI).The present study hypothesized that oxi

会议

diabetesshh pathwayoxidative stressmyocardial infarctioncardiac dysfunction

Liraglutide ameliorates glycometabolism and insulin resistance via GLUT4 upregulation in diabetic KK

Aim: Liraglutide has been used for treatment of type 2 diabetes mellitus since 2009.In this study, the anti-diabetic effect and mechanisms of liraglutide were investigated in spontaneous diabetic anim

会议

liraglutideglycometabolisminsulin resistanceGLUT4KKAy mice

Expression change of insulin receptor in liver cell of type 2 diabetic rats after duodenal jejunal b

Aim: To study the effects of duodenal jejunal bypass (DJB) surgery on the expression of insulin receptor (InsR) in the liver tissue of type 2 diabetic (T2DM) rats, and explore the relationship between

会议

duodenal-jejunal bypass surgerytype-2 diabetesinsulin receptorliver cell

Homocysteine induces C-reactive protein expression in rat smooth muscle cells via NMDAr-ROS-MAPK sig

Aim: As an inflammatory marker, C-reactive protein (CRP) plays a direct role in atherosclerotic process.Homocysteine (Hcy) is largely accepted as an independent risk factor for cardiovascular diseases

会议

homocysteineC-reactive proteinvascular smooth muscle cellsinflammationathero

Pioglitazone exacerbates the hepatic steatosis and suppresses serum cholesterol clearance in two ani

Aim: Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) frequently coexist as they share the pathogenic abnormalities of excess adiposity and insulin resistance.The insulin s

会议

pioglitazonehepatic steatosislipids metabolismT2DM

To compare the gastric ulcer induced by different non-steroidal anti-inflammatory drugs in mice

Aim: We try to establish a reliable and quantitative ulcer model to evaluate mucosa protecting drug.Methods: The Kunming mice was used, 10 mice in each group, take aspirin 32, 64, and 128 mg/kg by gav

会议

non-steroidal anti-inflammatory drugsgastric ulceraspirinindomethacindiclofe