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SOD是生物体内抵御O_2~-毒性的主要酶系,已用于治疗类风湿,放射病等,最近已有资料表明,SOD还具有抗肿瘤和抗心肌梗塞作用,是一具有开发前景的药物。作用机理 SOD催化O_2~-的歧化反应的进行,而O_2~-的歧化本身就为一快速自动反应过程,研究表明:在pH7.8的液相中,这种自动歧化反应(非酶促)的速率常数为8×10~4M~(-1)S(~-)。但是,O_2~-的这种反应为二步反应,O_2~-在第一步反应(碰撞机会)的半减期与O_2~-起始浓度成反比,例如,
SOD is the main organism against O 2 - toxicity of the major enzymes, has been used to treat rheumatoid, radiation sickness and other recent data show that SOD also has anti-tumor and anti-myocardial infarction, is a promising drug development. The action mechanism of SOD catalyzes the disproportionation reaction of O 2 - -, while the disproportionation of O 2 - itself is a rapid and automatic reaction process. The results show that in the liquid phase of pH7.8, this auto disproportionation reaction (non-enzymatic) The rate constant is 8 × 10 ~ 4M ~ (-1) S (~ -). However, this reaction of O_2 ~ - is a two-step reaction, and the half-life of O_2 ~ - in the first reaction (collision opportunity) is inversely proportional to the starting concentration of O_2 ~, for example,