Comparative study of dual source CT perfusion Among hepatocellular carcinoma, hepatic hemangiom and

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  urpose: To investigate the diagnostic value of dual-source CT perfusion imaging(CTPI)features in hepatiocellular carcinoma(HCC) , hepatic hemangiom and Focal nodular hyperplasia(FNH).and to determine whether CTPI can evaluate the blood supply of hepatic solid tumors.Materials and Methods: 10 patients with HCC, 8 patients with hepatic hemangiom and 8 patients with FNH underwent dual-source CT perfusion scans.Measurements and calculations of Blood flow(BF), blood volume (BV), hepatic arterial perfusion(HAP),time to start(TTS),time to peak(TTP)and permeability of surface area product (PS) of lesions and normal liver tissue were performed by two independent blinded radiologists.perfusion parameters were tested overall for statistically significant differences by using the repeated-measures analysis of variance.Results BF,BVand HAP values were higher in lesions than in normal liver tissue in groups (P<0.05).BF, BV values in lesion were higher in FNH group than both in HCC group and hepatic hemangiom group (P<0.01) , and were no statistical difference between HCC group and hepatic hemangiom group(P>0.05).TTS,TTP values were lower in lesions than in normal liver tissue of HCC group and FNH group(P<0.05) ,and were higher in hepatic hemangiom group .TTS ,TTP values from high to low was hepatic hemangiom group, HCC group and FNH group in order(P<0.05).PS values from high to low was FNH group, HCC group and hepatic hemangiom group in order (P<0.05)Conclusion Dual-source CTPI can provide much more information about the hemodynamics,blood supply and distribution features of HCC, hepatic hemangiom ground and FNH, which is helpful in differential diagnosing of hepatic solid tumors.
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