Differences between Human Cutaneous and Uveal Melanoma in Animal Model Running Head:Uveal and Cutane

来源 :BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会) | 被引量 : 0次 | 上传用户:tropicalpalmetto
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  Uveal melanoma (UM) and cutaneous melanoma (CM) both derive from melanocytes.The Henry C.Witelson Ocular Pathology Laboratory, McGill University, Montreal, Canada, has previously described an animal model of UM.The aim of this current study is to observe the differences between CM and UM cells in an animal model.Fifteen rabbits were injected with 1×106 human CM cells (WM-266-4) (Group A), and another fifteen with 1×106 human UM cells (92.1) (Group B), into the suprachoroidal space of the right eye.After the 4th week, one animal per week was sacrificed in order to document disease progression.The remaining animals were sacrificed at the end of the experiment.The eyes, lungs and livers were collected and studied histopathologically.Group A: 92.8% presented intraocular tumor development.Tumor growth toward the anterior chamber was found in 76.9% of the animals.
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