【摘 要】
：
Lynch syndrome (LS),also known as hereditary nonpolyposis colorectal cancer (HNCC),is an autosomal dominant inherited disease.Colorected cancer (CRC) was one of
【机 构】
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KeyLaboratoryofMolecularBiophysicsofMinistryofEducation,SchoolofLifeScienceandTechnology,HuazhongUni
【出 处】
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湖北省细胞生物学学会2015年会员代表大会暨学术研讨会
论文部分内容阅读
Lynch syndrome (LS),also known as hereditary nonpolyposis colorectal cancer (HNCC),is an autosomal dominant inherited disease.Colorected cancer (CRC) was one of the main Lynch syndrome-associated tumors.In addition to CRC,LS had a high risk of other extracolonic tumors,such as endometrial cancer (EC),ovarian cancer,gastric cancer,intrahepatic cholangiocarcinoma,urological cancer,and skin cancer,which had been associated with potentially germline mutations in a group of DNA mismatch repair (MMR) genes (MLH1,MSH2,MSH6,PMS1 and PMS2).LS was mainly caused by the mutation of MLH1 and MSH2 genes.In a minority of cases,mutations have been described in other MMR genes like PMS1 and PMS2.
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