【摘 要】
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Aristolochic acid (AA) is a mixture of structurally related nitrophenanthrene carboxylic acids (mainly A-Ⅰ and AA-Ⅱ) derived from Aristolochia species, wh
【机 构】
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DepartmentofChemistry,HongKongBaptistUniversity,HongKongSAR,China
【出 处】
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DaLian Internationall Symposia and Exhibition on Chromatogra
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Aristolochic acid (AA) is a mixture of structurally related nitrophenanthrene carboxylic acids (mainly A-Ⅰ and AA-Ⅱ) derived from Aristolochia species, which has been used as herbal medicines to treat tumours, snake bites, obstetrics, rheumatism, etc.Recent research, however, has shown that uncontrolled exposure to plant extracts containing AAs have might result in nephropathy in the form of rapidly progressive renal failure and possible cancer of the urinary tract at later stages.Aristolochic acid nephropathy (AAN) has been observed in patients due to the formation DNA-adducts with the exposed AAs through metabolic activation.As a result, the use of herbal medicines containing AA-Ⅰ and AA-Ⅱ have been banned in many countries or regions including Hong Kong, USA and Europe.However, AA is still being found in some slimming drugs and herbal remedies.
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