Hollow mesoporous silica nanoparticles(HMSN)with controllable pore size and particle size were successfully synthesized.This approach adopted a templating sol-gel technique with the polymerization of MMA as the organic vesicle and cetyltrimerhylammonium bromide(CTAB)as the vesicle surfactant.By controlling the adding time of mineralizing agent,the hollow in HMSN was formed by the prehydrolysis of tetraorthosilicate and the nanoparticles containing MMA were achieved by the self-assembly of vesicles.The HMSN were developed after calcination.By altering the ratio,HMSN with controllable pore size(5-15 nm)and particle size(40-110 nm)were produced.The biocompatibility of synthesized HMSN was tested by CCK-8 and cellular uptake assay.This novel technique has practical applications in the control release of large molecular drugs.