Purpose Activating mutations of c-Kit have been associated with gastrointestinal stromal tumors (GISTs).Unfortunately,primary or acquired resistance to c-Kit inhibitors,such as imatinib and sunitinib,
Object Photodynamic therapy (PDT) is a regulatory approved modality for treating a variety of malignant.It utilizes the destructive power of reactive oxygen species generated via visible light irradia
Object Colorectal carcinoma is a frequent cause of cancer-related death in men and women.miRNAs (microRNAs) are endogenous small non-coding RNAs that regulate gene expression negatively at post-transc
畲药白山毛桃根是少数民族畲族常用药物,具有清热解毒,消肿利湿的功效,民间主要用于治疗胃癌、肠癌、白血病、肝硬化等疾病.但是,对于其确切疗效及其可能的机制,目前缺乏实验研究依据.黑色素瘤是一种恶性程度较高、死亡率高的肿瘤,尚无有效的治疗方法.黑色素瘤细胞株M21细胞是国内外研究黑色素瘤的常用细胞株.本课题对畲药白山毛桃根的有效成分进行提取收集,以M21细胞为研究对象,采用体外细胞培养系统,观察畲药白
Background To validate cadherin-17 (CDH 17) as a potential therapeutic target for gastric cancer (GC) and to investigate the antitumor mechanisms associated with CDH17 inhibition in GC.Methods GC tiss
Purpose The aim of this study is to explore the mechanisms of the cancer cell resistance toward dihydroartemisinin (DHA),one of the main metabolites and derivatives of artemisinin,which has exhibited
目的 原纤毛是以微管为结构基础并突出于细胞表面的"天线状"细胞器,其结构和功能异常与肿瘤发生发展密切相关.文献报道,NEK-8参与调控原纤毛结构,但其自身表达和活性调控机制、及其调控原纤毛结构的机制均有待于进一步研究.我们首次发现pVHL参与NEK-8的表达调控,并将探讨相关机制.
Objective Cell migration,adhesion and invasion are the basic forms and critical steps for tumor metastasis.Ganoderma lucidum,also called Lingzhi in China,is a traditional Chinese medicine exhibiting a
Objeetive Platycodin D (PD),a triterpenoid saponin isolated from the root of Platycodon grandiflorum A.DC,possesses anti-cancer effects in varieties of cancer cell lines.This study aims to study the a
目的 研究新四环二萜类化合物GA-13315(以下简称GA)的抗肿瘤活性,并探讨其对肿瘤细胞DNA拓扑异构酶的作用及机制.方法 以人胃腺癌细胞株SGC-7901(低分化)和MKN-28(高分化),人结肠腺癌细胞株LOVO(未分化)和HCr-116(低分化),人低分化肺腺癌细胞株GLC-82和AGZY-83a人肝细胞癌SMMC-7721(低分化)和HepG-2(高分化)为模型,采用MTT法检测化合物