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The correlation between free radicals and cancer has attracted a great deal of attention in recent years.Many studies have shown that free radical is a key factor of causing cancer [1,2].And H2 is a free radical scavenger with unlimited potential [3].Biomedical magnesium(Mg)could release H2 in the biodegradation process,so it might have antitumor properties.In this study,pure Mg metal(P-Mg)was subjected to anodic oxidation plus heat treatment to get AO-HT-Mg covered with MgO.The bioactivity and anti-corrosive quality of Mg metal have improved after surface modification treatment in SBF immersion test.In the cell experiments,the P-Mg and AO-HT-Mg could remove free radicals in the MRMT-1 cells by releasing H2,and AO-HT-Mg was better than P-Mg.There were four group mice with blank group(normal mice),control group(mice with tumor),P-Mg group(tumor and P-Mg metal)and AO-HT-Mg group(tumor and AO-HT-Mg metal)at the animal experiment.Both P-Mg and AO-HT-Mg could suppress the tumor growth and the P-Mg has a higher inhabit ability than AO-HT-Mg in the initial stage.However,the AO-HT-Mg showed better in later.The results confirm Mg metal has antitumor properties in vivo,and it is possible to optimize its properties to inhibit tumor growth by regulating H2 releasing rate through surface modification.