【摘 要】
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Objective To explore the feasibility and mechanism of NSCs transplantation into lateral cerebral ventricle for treating manganismus symptom.Materials and me
【机 构】
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Department of Human Anatomy, Guangxi Medical University, Nanning 530021, China
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
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Objective To explore the feasibility and mechanism of NSCs transplantation into lateral cerebral ventricle for treating manganismus symptom.Materials and methods:32 two-weeks-old mice were divided into 4 groups including normal group(NG),transplantation group(TG),pseudo-transplantation group(PG) and manganismus group(MG),and manganismus mouse was induced by 2-weeks intraperitoneal administration of 20mg/kg·d manganese chloride solution.Then mice in TG were transplanted into lateral cerebral ventricle with unicell suspension of BrdU-labeled NSCs from new-born mouse hippocampus,mice in PG were only injected with phosphate buffered saline from the same position,while mice in NG and MG received no treatment.After a week resting,all experimental mices neurobehavioral scores were evaluated by Morris Water Maze(MWM).The surviving,migration,differentiation of transplanted NSCs were detected by single-labeling and double-labeling methods of immunohistochemistry.
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