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ObjectiveTo evaluatethedifferenceofCTquantitativeparametersamongdifferentsubtypeofperipheralpulmonary adenocarcinomamanifestingasground-glassnodule(GGN). Methods 181peripheralpulmonaryadenocarcinomasshowingGGNconfirmedbypathologywereretrospectivelyanalyzed.All pathologicspecimenwereclassifiedintopreinvasivelesions(AtypicalAdenocarcinomaHyperplasia,AAHorAdenocarcinoma inSitu,AIS),MinimallyInvasiveAdenocarcinoma(MIA)andInvasivePulmonaryAdenocarcinoma(IPA)accordingtothenew lungadenocarcinomaclassificationcriteria.Allrawdatasetswerereconstructedinto0.625mmor1mmofthickness,andthenthe borderofthenodulewasmanuallydepictedslicebyslice.Themaximumcross-sectionaldiameter,verticaldiameter perpendiculartothemaximumdiameter,meandensityandvolumewereautomaticallycalculatedbyanin-housesoftware program(Exact1.0,ShanghaiUnitedImagingHealthcareco.,ltd.).Then,themeansizeandmassofthenodulewerecalculated. Stepwisediscriminantanalysiswasusedtoestablishthediscriminantmodel. Results ThefourMDCTquantitativeparameters,includingmeansize,volume,mass,andmeandensityweresignificantly different(P<0.001)amongthethreegroups.Thefourparametersweresignificantlydifferent(P<0.001)betweenpreinvasive lesionsandIPA,orbetweenMIAandIPA.Nodifferenceswerefoundinallthefourparametersbetweenpreinvasivelesionand MIA.Meansize,meandensityandmasswereselectedaccordingtostepwisediscriminantanalysis.TheaccuracyofBayesmode was71.3%and69.6%byusingsubstitutionmethodandcrossvalidationmethodrespectively. Conclusion Theground-glassnodulewithlargermeansizeandvolume,greaterdensityandmass,hasahigherprobabilityof IPAthanthatofMIAorpreinvasivelesion.Meansize,meandensityandmassaretheimportantparameterstodifferentiatethe differentsubtypesofpulmonaryadenocarcinomas.