基于海洋天然产物cyclooroidin构建新型抗炎药物

来源 :中国化学会第十届全国天然有机化学学术会议 | 被引量 : 0次 | 上传用户:asdfghjki
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醛糖还原酶(Aldose Reductase,EC 1.1.1.21,ALR2)与多种疾病的发生发展相关.越来越多的研究表明,ALR2可启动和加速氧化应激来诱导NF-kB激活,产生系列炎症反应及肿瘤细胞增殖.ALR2抑制剂(ARI)可有效抑制多种疾病相关的炎症介质,控制炎症的发生和发展.
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