The materials parameters in micro-environment in which stem cells reside can inflence their fate,and synthetic materials have recently been designed to emulate these regulatory processes for various medical applications,especially for tissue engineerin and regenerative medicine.Chemical functional clusters,ligands inspired by the natural extracellular matrix,cell–cell contacts,and growth factors have been incorporated into synthetic materials with precisely engineered density and presentation.Furthermore,material architecture and mechanical properties are material design parameters that provide a context for receptor–ligand interactions and thereby contribute to fate determination of uncommitted stem cells.Recently much effort has been making in understanding of interactions between materials and stem cells and biomaterials development for cellular control,meanwhile the design of more sophisticated and robust synthetic materials can address future challenges in achieving spatiotemporal control of cellular phenotype and in implementing histocompatible clinical therapies.Such information will have significant influence to Bio-Nano Integrated Manufacturing for tissue engineering and regenerative medicine.