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Dyslipidemia is a risk factor of cardiovascular disease and is therefore a major target for primary and secondary prevention.Maintaining a healthy diet and lifestyle reduces cardiovascular risk.Dietary habits are an important instrument of active care for maintaining the populations health.To determine if intake the Pre-Germinated Brown Rice will reduce the blood-fat of the patients with dyslipidemia and to evaluate the effectiveness of the Pre-Germinated Brown Rice as a new staple food in reducing the blood-fat,physical examinations and blood lipids were measured at baseline in four communities of Wuxi,then 191 employees (95 males,96 females,mean age 56.70±6.698 years) who has dyslipidemia were assigned to two groups: one group get intervention (INT): Pre-Germinated Brown Rice was administered to members in the group during 12 weeks in a daily dose of 150g instead of equivalent staple food,and with no dietary habits and lifestyle changing; another group of control (CON) with no intervention at all.Blood lipids were measured 12 weeks after the intervention.The results showed that after 12 weeks intervention the patients in INT (n=94) that received 127.18(±10.662)g of PGBR instead of equivalent staple food had significantly lower TC [-0.69(±0.497)mmol/L,P<0.001],lower TG [-0.24(±0.602)mmol/L,P=0.001],lower LDL-c [-0.81(±0.513)mmol/L,P<0.001],and higher HDL-c [0.14(±0.187)mmol/L,P=0.018] compared with the CON [-0.16(±0.246)mmol/L,0.02(±0.382)mmol/L,-0.25(±0.298)mmol/L,0.09(±0.116)mmol/L respectively].And the effective rate of the INT (80.85%) is significant higher (P<0.001) than the CON (18.55%).It is concluded that intake the Pre-Germinated Brown Rice instead of equivalent staple food significantly reduced the blood lipid level of the patients with dyslipidemia.And it is an effective and well accepted method for secondary prevention of dyslipidemia.