【摘 要】
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Dramatic increases in the levels of multiple-antibiotic resistance associated with Klebsiella pneumoniae,particularly to agents of last-resort such as carbapenems and polymyxins,pose a major emerging
【机 构】
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上海交通大学微生物代谢国家重点实验室/生命科学技术学院
论文部分内容阅读
Dramatic increases in the levels of multiple-antibiotic resistance associated with Klebsiella pneumoniae,particularly to agents of last-resort such as carbapenems and polymyxins,pose a major emerging global problem.Acquisition and spread of resistance-and/or virulence-associated genes,as well as the wider evolution of bacteria,are strongly associated with certain types of mobile genetic elements (MGEs),including plasmids,insertion sequences (ISs),transposons,integrons and associated gene cassettes,prophages,integrative and conjugative elements (ICEs) and genomic islands (GIs).This study aims to investigate the landscape of mobile genome,with a focus on antibiotic resistance-associated factors in carbapenem-resistant Klebsiella pneumoniae.
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