【摘 要】
：
Genotoxic agents can cause DNA or (and) chromosome structure or (and) quantity change.They are related to many diseases such as fetal malformation, cancer, parkinsonism, alzheimers disease.Environment
【机 构】
：
Guang dong Provincial Center for Disease Control and Prevention, Guang zhou 510300
【出 处】
：
2015毒性测试替代方法与转化毒理学(国际)学术研讨会
论文部分内容阅读
Genotoxic agents can cause DNA or (and) chromosome structure or (and) quantity change.They are related to many diseases such as fetal malformation, cancer, parkinsonism, alzheimers disease.Environmental pollutants may interact with people through various ways.Screen and evaluation of genotoxicity of environmental pollutants are important.
其他文献
Age-related macular degeneration (AMD) is associated with many factors, such as aging,family history, smoking, hypertension, hypercholesterolemia and so on.Due to the rapid increase in the age of the
The embryonic stem cell test (EST) has recently been utilized as an alternative test for developmental toxicity despite its numerous improvements across a wide range of species, many issues still rema
Quantum dots (QDs), considered as altematives of conventional fluorescent dyes, are an increasingly used class of nanoparticles in biomedical imagery and target drug delivery.Owning to their unique ph
目的 手足综合症是由药物引起的手掌-足底感觉迟钝及肢端红斑,也称之为掌跖感觉丧失性红斑,是一种严重皮肤不良反应事件,主要发生在受压区域.传统化疗药卡培他滨是新一代口服嘧啶类药物,主要用于治疗晚期乳腺癌及结直肠癌,药效显著,且病人耐受性良好,然而其主要不良反应手足综合症的发生率可高达60％,严重影响了病人的生活质量,并极大的限制了卡培他滨的临床应用价值.深入研究卡培他滨引起手足综合症的分子机制和干预
In the European Union animal testing has been eliminated for cosmetic ingredients while the US or other countries may still request data from animal studies.The use of read-across and predictive toxic
Skin sensitization is a key toxicological endpoint for cosmetic ingredients, with a ban for animal testing in Europe.Alternative tests have been developed some of which are already accepted by OECD as
目的 环境化学诱变物数量巨大、种类繁多,人类长期接触可导致动脉硬化、衰老、肿瘤、畸形、不孕等严重后果.因而对环境中诱变物进行致突性检测具有重要意义.然而目前,现有的基因突变检测方法均存在手段繁复,周期长,费用高、误差大等问题.另外,有些试验需要荧光和放射性标记,会对试验人员健康造成伤害.因此,迫切需要发展能够无标记、快速、原位、实时检测基因突变的试验新方法.
Bisphenol A (BPA), an environmental estrogenic endocrine disruptor, is used for producing polycarbonate plastics and epoxy resins.Amounting studies showed significant bioaccnmulation of BPA in the fet
目的 明确3,3-二吲哚甲烷(3,3-Diindolylmethane,DIM)是否能通过抗氧化应激以及抗炎性反应来预防或者延缓UVA诱导的光老化.方法在本研究中,我们选择人角质形成细胞HaCaT和昆明小鼠建立皮肤光老化模型来研究DIM是否具有预防由UVA诱导的光老化能力.
目的 研究全氟辛烷磺酸(perfluorooctane sulphonate,PFOS)诱导人肝癌细胞株HepG2凋亡效应及可能的机制.方法接种HepG2细胞24h后,用不同浓度PFOS处理48h,采用MTT法观察细胞存活率,采用流式细胞术测定细胞凋亡率;实时荧光定量PCR法测定细胞内Bcl-2、Caspase-3、Bax、AIF、Cyc-C、Caspase-6 RNA表达水平;Western B