Triazole drugs including Fluconazole,Itraconazole and Voriconazole have been prevalently used in the antiinfective therapy and also exhibit good anti-MRSA potency.
5-Fluorouracil(5-FU)is a well-known antitumour agent widely used for the treatment of solid tumors.However,its clinical use is limited by many disadvantages such as short half-life,low selectivity,and
A series of novel sulfanilamide nitroimidazoles were synthesized via unique C-N cleavage of cyclic sulfanilamides by azole ring.Their structures were characterized by 1H NMR,13C NMR,IR,MS and HRMS spe
Fluconazole is a well known first-line antifungal drug recommended by World Health Organization and is prevalently used to treat fungal infections by Candida albicans and Cryptococcus neoformans with
Benzimidazoles are an important class of nitrogen-containing heterocycles,they display extensively potential applications as medicinal agents,supramolecular blocks as well as functional materials and
Chalcones bearing typical diaryl enone backbone are widely present in most natural fruits and vegetables,and have also been shown to display a diverse array of pharmacological activities,especially in
Quinazolinones have emerged as new potential antimicrobial agents because of their broad spectrum of in vitro activity and their in vivo chemotherapeutic activity.
Nitrogen heteroarenes widely present in naturally occurring products and synthetic bioactive molecules,and as core structures of currently marketed drugs[1].