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Objective EBV-associated gastric cancer(EBVaGC)is defined as a distinct gastric adenocarcinoma subtype with EBV infection and always over-express programmed death ligand-1(PD-L1).CKLF-like MARVEL transmembrane domain containing protein6(CMTM6)is a ubiquitously expressed protein that binds PD-L1 and maintains its cell surface expression.