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The drug delivery to the lungs has attracted dramatically increasing attentions for the treatment of local and systemic diseases.Dry powder inhalers (DPI) offer the advantages of propellant-free,avoidance of the coordination between inhalation and actuation and improved stability of bioactive agents.The spray-drying has been proved to be an effective approach to prepare drug particles with the size in the inhalable range (< 7 pr).Lactose is a general excipient to be used in dry powder formulations for inhalation.