Cholesterol granuloma (CG) is usually found in middle ear ,papillae, orbits, petrous apex, and choroid plexus, being highly uncommon in the skull.Here, we report a patient with CG of suprasellar and sellar, manifesting as progressive decreased-vision in the both eyes accompanied by dizziness, headache, nausea and vomiting who was successfully treated with Traditional Chinese medicine.He suffered from the first relapse after radical surgery and the second recurrence after radiotherapy.However, when herbal medicine and Java brucea fruit soft capsule were administered to the patient, his tumor mass decreased dramatically, and clinically, the related symptoms and signs resolved significantly as therapy progressed within several months.Furthermore, he was still alive with free disease progress along with follow-up.Overall, Chinese herbal formula and Java brucea fruit soft capsule treatment was beneficial in improving the patients quality of life, in addition the treatment may be good antineoplastic agent for tumor which are believed to be safe, especially the cerebral tumor.