Organofluorine chemistry is an active research topic because introduction of fluorine atom(s) could have a significant effect on parent molecules chemical,physical,and biological properties.Nucleophilic fluoroalkylation reaction is one of the important methods to introduce fluorinated group into organic molecules.However,the introduction of fluorine poses a negative effect on the thermal stability of many α-fluoro carbon anion and corresponding nucleophilic fluoroalkylation reactions.Our group investigated the fluorinated 1,3-dicarbonyl compounds,a new type of fluorine-containing building-block,which participate in some of the fluoroalkylation reactions and applicate in some highly stereoselective and multicomponent reaction systems to obtain some structure which is unable or difficult to obtain directly fluoroalkylation raction.The success on organic and medicinal chemistry of this fluorinated building-block is summarized in an apple tree with many red apples (published work) and green apples (unpublished work).