Broad, hybrid capture-based next generation sequencing in metastatic colorectal cancer facilitated p

来源 :第十八届全国临床肿瘤学大会暨2015年CSCO学术年会 | 被引量 : 0次 | 上传用户:2km
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Objective: Patients with metastatic colorectal cancer are now recommended to profile for RAS and BRAF mutations before receiving cetuximab or panitumumab.However, lots of patients with both RAS and BRAF wild-type tumors determined by non-NGS testing might still notrespond due to the presence of additional gene mutation such as PIK3CA or PTEN.
其他文献
Objective: The application of mammography benefits more and more patients by an increased detection of smaller invasive tumors, and it would be helpful if mammography could be used in determining prog
Objective: Tamoxifen resistance leads to lethality in a substantial fraction of estrogen positive breast cancer patients.The aim of the study is to identify the effect of PAK4 on tamoxifen resistance
目的:探讨TRAP1在乳腺病变恶性转化过程中的可能作用,分析其表达水平与乳腺癌各病理参数间的关系。方法:收集2009-04-15-2012-04-15中国医科大学附属第一医院诊治的低级别导管内癌(低级别DCIS)、高级别导管内癌(高级别DCIS)各15例和浸润性导管癌100例,以乳腺导管普通型增生(UDH)、乳腺不典型增生(ADH)各15例作为对照,应用免疫组织化学法检测上述标本中TRAP1的表达
目的:研究鹿茸多肽对乳腺癌骨转移肿瘤生长及破骨细胞的影响。方法:40只雌性SD大鼠随机分为假手术组、模型对照组、唑来膦酸组和鹿茸多肽组,每组10只。假手术组在大鼠胫骨内注射生理盐水,其他3组通过于胫骨内注射乳腺癌细胞(MRMT-1)建立乳腺癌骨转移模型,各组分别给予对应药物,模型组造模后不予处理,给药20天。
目的:乳腺癌是在我国女性中发病率居首的恶性肿瘤,且发病率正以3%的速度逐年上升,2014年已达25.89%.目前,逐渐规范的手术及辅助治疗使得乳腺癌的治愈率逐渐升高,但上肢淋巴水肿作为术后主要的并发症之一,对医生而言是一项具有挑战的问题.
Objective: Cytokine-induced killer (CIK) cells represent a realistic approach in cancer immunotherapy with confirmed survival benefits in the context of metastatic solid tumors that are unmanageable u
Objective: D2 gastrectomy is a standard procedure of curative resection for gastric cancer.This study aims to develop a simple and reliable prognostic scoring system for gastric cancer with D2 gastrec
Objective: To evaluate radiochemotherapeutic sequence for pathological stage N2 rectal cancer in the era of oxaliplatin-based adjuvant therapy.Method: Treatment outcomes and impact of different sequen
目的:本文旨在对18F-FDG-PET/CT早期预测复发转移乳腺癌缓解率的价值进行研究。方法:选择2007年~2014年复发转移的乳腺癌患者18例,所有患者均于治疗前和化疗一周期后均行PET/CT检查1次,统计分析客观缓解(OR)组与未达客观缓解(non-OR)组患者之间PET/CT1、PET/CT2、SUV、SUV变化率比较,代谢反应组与代谢无反应组患者OR、DCR的比较。
Objective: The prognosis for unresectable metastatic colorectal cancers is poor, and improved therapies are needed.Recent studies have shown the activated NLRP3 inflammasome was one of the machanism t