MiR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression

来源 :泌尿生殖肿瘤华夏医学论坛2016暨长城国际泌尿男科转化医学论坛2016 | 被引量 : 0次 | 上传用户:ahhshpl
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Objective: MicroRNA-34a (miR-34a) is a tumor suppressor gene,which inhibits abnormal cell growth by regulating the expression of other genes.However,the role of miR-34a regulation sirtuin 1 (SIRT1) in prostate cancer is not clear.
其他文献
Objective: The c-met proto-oncogene pathway plays an important role in tumor progression of various cancers.However,the impact of c-met pathway on renal cell carcinoma (RCC) remains controversial.Meth
Objective: The implications of magnetic resonance imaging-targeted biopsy (MRI-TBx) versus transrectal ultrasound-guild biopsy (TRUS-Bx) are not well understood.To update the current evidence on the d
Objective: Penile cancer (PeCa) is a relatively rare tumor entity but possesses higher morbidity and mortality rates especially in developing countries.To date,the concrete pathogenic signaling pathwa
Objective: UroVysion FISH has been used for screening bladder cancer in western countries,but still limited in China.This non-invasive assay is also practical for detecting upper tract urothelial carc
Objective: To discuss the difference in the effect between the laparoscopic radical prostatectomy (LRP) and robot-assisted laparoscopic prostatectomy (RALP) on sexual function.Methods: A total of 204
Objective: To report our laparoscopic partial nephrectomy (LPN) experience and assess the role of learning curve and RENAL score impact on the outcomes of LPN,focusing on shortening the procedure time
Objective: Centromere protein H (CENPH) is one of the essential components of the human active kinetochore which close links with carcinogenesis.Its biological and clinical value of prognostic predict
Objective: Gene expression analysis is widely used in most of studies of transcriptomic.If the cryopreserved samples storage time may influence the expression levels of genes is unknown.We aim to test
Objective: Nucleolar and spindle-associated protein 1 (NUSAP1) is a microtubule-binding protein that plays an essential role in mitosis and cancer.Previous studies have demonstrated that NUSAP1 expres
Objective: The management of stage 1 and grade 3 (T1G3) bladder cancer continues to be controversial.Although the transurethral resection of bladder tumor (TURBT) followed by intravesical chemotherapy