Over-fertilization is common in greenhouse vegetable crop production.Repeated application of manure without taking crop nutrient needs into account is a common practice of greenhouse vegetable production.Fertilizer cost is relatively a small percentage of overall cost and often gives way to maximize production.Such over-fertilization, along with three to four crops per year, often leads to rapid nutrient accumulation, soil salinity, and acidification.When considering fertilization in greenhouse vegetable production, 4Rs —right material (choice of nutrient sources), right placement,right (application) rate and right timing—sums up the nutrient management.Matching crop needs at different stages of growth and development requires understanding of the crop, nutrient release patterns from nutrient sources and nutrient delivery.It is important to have a clear idea about both the supply and demand, which could be done by soil and plant testing, respectively.To cope with current over-fertilization in greenhouse vegetable production, cover cropping, slow release fertilizers, arbuscular mycorrhizal fungi inoculation and vegetable grafting may provide solution for sustainable production, improving nutrient efficiency, and reduced nutrient leaching.