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  5. Characterization of thermo-sensitive amphiphilic comb-like copolymer and its application in controll

Characterization of thermo-sensitive amphiphilic comb-like copolymer and its application in controll

来源 :2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：xiexiebinbin
【摘 要】
：
An amphiphilic thermo-sensitive comb-like copolymer, poly (D, L-lactide)-graft-pullulan (PL), can disperse and self-assemble into thermo-responsive nanoparticles which is available in controlled drug
【作 者】
：
Xiao-Jiao Tang Yue Ma Wei-Fang Ren Ling-Ling Huang Shou-Nan Liu Li-Yang Ju-Ju Zhang 
【机 构】
：
Department of Pharmaceutics,Shenyang Pharmaceutical University,103 Wenhua Road,Shenyang 110016,China
【出 处】
：
2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
【发表日期】
：
2014年8期
【关键词】
：
Poly(D L-lactide)-graft-pullulan Microwave Thermo-sensitive Self-assembly Nanopa 
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论文部分内容阅读
　　An amphiphilic thermo-sensitive comb-like copolymer, poly (D, L-lactide)-graft-pullulan (PL), can disperse and self-assemble into thermo-responsive nanoparticles which is available in controlled drug delivery system.A microwave-assisted solution polymerization was applied to synthetize PL in a monomode microwave reactor.Dynamic light scattering technique (DLS), and turbidity measurements using UV-VIS spectrophotometry were adopted to characterize the reversible thermo-sensitive properties of the amphiphilic copolymer.
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