How do abnormalities in the brain's spontaneous activity translate into symptoms in schizophren

来源 :首届浙江省精神卫生专科联盟学术会议暨第四届精神病学与临床心理学国际高峰论坛 | 被引量 : 0次 | 上传用户:ww447978636
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  Schizophrenia is a complex neuropsychiatric disorder with a variety of symptoms that include sensorimotor,affective,cognitive,and social changes.The exact neuronal mechanisms underlying these symptoms remain unclear though.Neuroimaging has focused mainly on the brains extrinsic activity,specifically task-evoked or stimulus-induced activity,as related to the sensorimotor,affective,cognitive,and social functions.Recently,the focus has shifted to the brains spontaneous activity,otherwise known as its resting state activity.While various spatial and temporal abnormalities have been observed in spontaneous activity in schizophrenia,their meaning and significance for the different psychopathological symptoms in schizophrenia,are yet to be defined.The first aim in this paper is to provide an overview of recent findings concerning changes in the spatial (e.g.,functional connectivity) and temporal (e.g.,couplings between different frequency fluctuations) properties of spontaneous activity in schizophrenia.The second aim is to link these spatiotemporal changes to the various psychopathological symptoms of schizophrenia,with a specific focus on basic symptoms,formal thought disorder,and ego-disturbances.Based on the various findings described,we postulate that the spatiotemporal changes on the neuronal level of the brains spontaneous activity transform into corresponding spatiotemporal changes on the psychological level which,in turn,leads to the different kinds of psychopathological symptoms.We consequently suggest a spatiotemporal rather than cognitive or sensory approach to the condition,amounting to what we describe as "Spatiotemporal Psychopathology".
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