【摘 要】
：
The present study was conducted to investigate the effect of early feedrestriction on protein kinase Cα(PKCα) expression in pulmonary arterioles,which has been revealedto promote pulmonary vascular re
【机 构】
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Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls,Nanjing Agricultural
【出 处】
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中国畜牧兽医学会2008年学术年会暨第一届中国兽医临床大会
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The present study was conducted to investigate the effect of early feedrestriction on protein kinase Cα(PKCα) expression in pulmonary arterioles,which has been revealedto promote pulmonary vascular remodeling in pulmonary hypertensive broilers.Methods: A total of 270 day-old mixedsex commercial broilers were randomly distributed to a normaltemperature Control group(NT),a low temperature Control group(LT) and a low temperature plus feedrestriction group(LR). The PHS incidence,the right/total ventricular weight ratio(RV/TV),the vesselwall area/vessel total area ratio(WA/TA),the mean media thickness in pulmonary arterioles(mMTPA)and the expression of PKCα in the pulmonary arterioles were measured weekly. Results: Lowtemperature treatment significantly increased the PHS mortality. The RV/TV,WA/TA and mMTPAvalues of group LT were significantly elevated Compared with those of group NT on d 35 and 42. TheLT chickens had increased PKCα expression Compared with their NT Counterparts on d 28 andafterwards. Feed restriction reduced the PHS mortality,RV/TV,WA/TA and mMTPA incold-exposed broilers. The LR chickens had much lower PKCα expression in pulmonary arterioiesthan the LT chickens.Conclusion: Early time feed restriction inhibited pulmonary vascular remodelingin broilers,which might be partly attributed to reduced PKCα expression in pulmonary arterioles.
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