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5. Activation of Kir4.1 is essential for activating thiazide-sensitive NaCl cotransporter(NCC)in the DC

Activation of Kir4.1 is essential for activating thiazide-sensitive NaCl cotransporter(NCC)in the DC

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：wangshilei19850715

【摘 要】

：

Kir.4.1(Kcnj10)is an inwardly-rectifying K channel expressed in the basolateral membrane of distal convoluted tubule(DCT).Loss-of-function mutations of Kir4.1 cause EAST or SeSAME syndrome and the ren

【作 者】

：

MingXiao Wang Xiao-Tong Su Wen-Hui Wang 

【机 构】

：

Department of Pharmacology,New York Medical College,Valhalla,NY;Department of Physiology,Zunyi Medic

【出 处】

：

2016年国际生理学学术大会

【发表日期】

：

2016年6期

【关键词】

：

Kir4.1 NCC DCT 

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　　Kir.4.1(Kcnj10)is an inwardly-rectifying K channel expressed in the basolateral membrane of distal convoluted tubule(DCT).Loss-of-function mutations of Kir4.1 cause EAST or SeSAME syndrome and the renal phenotype of the disease includes salt wasting,hypomagnesemia,metabolic alkalosis and hypokalemia.

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