For more than a decade,we have been exploring the macrocyclic and supramolecular chemistry of heteracalixaromatics A.l Owing to the self-tunability of a V-shaped cavity and electronic property by the interplay between the bridging heteroatoms and adjacent aromatic rings,heteracalixaromatics exhibit unique binding properties and have become powerful and versatile synthetic receptors to recognize diverse charged and electron neutral guest species.