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To improve the drawback points of conventional and commercially available medical adhesives, such as cyanoacrylate, aldehyde-based, and fibrin glue, new type bioadhesive has been prepared using medical and food additive sources as starting materials.Aldehyde groups could be easily introduced in dextran in the presence of sodium periodate in aqueous media and the extent of introduction also controlled.In vitro degradation speed of hydrogel prepared by mixing of aldehyded dextran with ε-poly(L-lysine) at 37℃ significantly varied by acetic anhydride concentration added to ε-poly(L-lysine) from < 5h to > 5 weeks.Bonding strength of the glue was 4 times higher than that of commercial fibrin glue and almost no cytotoxicity was observed, suggesting the development of novel self-degradable bioadhesive.The clinical application of this new and improved powder type glue, along with several examples of its successful usage, will be reported at the BITs 2nd Annual International Congress of Cardiology (ICC-2010).