Dual inhibition of RAF/MEK/ERK and PI3K/PDK/AKT signaling pathways with small molecules as anti-canc

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：yxl122702985

【摘要】

：

RAF/MEK/ERK pathways and PI3K/PDK/AKT pathways are involved in the regulation of cell growth and survival and are frequently dysregulated in human cancers,such as leukemia,melanoma and lung cancer.

【作者】

：

Qianbin LI

【机构】

：

Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Central South University,172 Ton

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Dual inhibitors RAS/MEK/ERK PI3K/PDK/AKT cancer

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　　RAF/MEK/ERK pathways and PI3K/PDK/AKT pathways are involved in the regulation of cell growth and survival and are frequently dysregulated in human cancers,such as leukemia,melanoma and lung cancer.

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Dual inhibition of RAF/MEK/ERK and PI3K/PDK/AKT signaling pathways with small molecules as anti-canc

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