Hydrophobic polypeptide hybrid block copolymers or “molecular chimeras” have drawn much attention due to their complex self-assembly and phase behavior making available a variety of nonclassical morphologies and hierarchical superstructures [1].Solid-state structure of molecular chimeras is mainly affected by the solvent toward hydrogen-bonding interactions or controlled by altering the blocks secondary structure [2].However,the majority of synthetic chemists are focusing on trying to control the primary structure or functionality of polymers,but so far a production of copolymers on a larger scale with the quality of biomacromolecules has not been achieved.A production of copolymers(PDMS-E grafted gelatin(PGG)polymers)on a larger scale with the quality of biomacromolecules has been achieved.It would be better for understanding the protein materials assembly processes for grasping the gelatin architecture and secondary structure.In the present study,anionic surfactant SDS and STSo are choosing to tune the electrostatic and hydrophobic interactions in PGG polymer solution.Bulk films have been created when the PGG polymer spontaneously self-organize into micro-scale patterns.The solid-state structure of PGG polymer is investigated by X-ray scattering(SAXS),transmission/scanning electron microscopy(TEM and SEM),atomic force microscopy(AFM).Infrared spectroscopy has revealed secondary structure changes of PGG polymer in SDS or STSo system.The phase behavior of PGG polymer is discovered to indicate that supramolecular interactions in biomacromolecules combining phase separation can bring higher performance and functionality into their materials.