目的：检测RASSF10在肝癌中的甲基化情况,分析RASSF10甲基化与肝癌的诊断和预后的关系,探索RASSF10对肝癌细胞功能的影响及作用机制。材料和方法：17株肝癌细胞系(SNU182,SNU387,HBXF344,SNU475,HepG2,BEL7402, LM3, Huh7, PLC/PRF/5, QGY7703, Huh1, BEL7404, BEL7405,QSG7701,Sk-hep
单宁酸(Tannic Acid,TA)是植物源性多酚类化合物,具有一定的抗癌活性且无毒副作用.内质网应激是抗肿瘤药物的新靶点,TA抗癌活性与内质网应激之间的关系尚不清楚.我们发现TA和顺铂(CDDP)能够呈剂量性依赖抑制肝癌细胞HepG2生长,其IC50分别为360 μM和1.8 μg/ml,用它们的IC50的一半浓度联合处理细胞,其药物联合作用指数(combination index,CI)小于
As an important component of tumor microenvironment, CD4+ CD25+ Tregs reduce antitumor immunity and promote angiogenesis and metastasis in breast cancer.
The androgen receptor (AR) is expressed in approximately 60% of Her2+ breast cancers (BC).However, the functional role of AR is less well understood in Her2+ BC.Activated AR can elicit transcriptional
Kindlin-2 is a novel focal adhesion gene mediating the cell-ECM (extra-cell matrix) adhesion.Tumor associated macrophages (TAMs) plays an important role in linking chronic inflammation to cancer progr
Background: Triple-negative breast cancer (TNBC) remains a major challenge clinically due to a lack of biological targets and aggressive disease course.Curcumol is a monomer composition isolated from
Esophageal cancer is one of the most common malignancies worldwide.DACT2 is frequently methylated in human lung, hepatic, gastric and thyroid cancers.The methylation status and function of DACT2 remai
As a highly malignant tumor, salivary gland adenoid cystic carcinoma (ACC)accounts for nearly 10% of all the epithelial salivary tumors and with a low 5-year survival rate less than 20% in highly meta
Background: To study the inhibition of retinoblastoma cell viability by two commonly usedautophagy inhibitors, chloroquine (CQ) and 3-methyladenine (3-MA),alone or in combination with the conventional
Pyruvate dehydrogenase (PDH) is the multi-enzyme complex of mitochondrion.Its catalysis is of great importance in the process of energy metabolism.PDH catalyzes the decarboxylation of pyruvic acid to