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Objective To investigate the dose erythromycin treatment of feeding intolerance in premature children efficacy.Methods 54 patients had feeding intolerance in preterm children were divided into treatment group and control group 31 cases 23 cases.Control group, conventional treatment, the treatment group based on conventional medical treatments plus low-dose erythromycin 3-5mg/kg.d, intravenous infusion, 1 second/day, 5-7 days of treatment.Results The total effective rate was 83.87%, compared with the control group was 43.78% higher efficiency (P <0.01), the difference was statistically significant.Conclusion Low dose erythromycin treatment of feeding intolerance in premature children have significant effects, no adverse reactions.