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  5. TRPC1 redistributes TRPC5 in the surface membrane and prevents its cholesterol-and caveolin-dependen

TRPC1 redistributes TRPC5 in the surface membrane and prevents its cholesterol-and caveolin-dependen

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：wdhpll
【摘 要】
：
The widely expressed Transient Receptor Potential Canonical (TRPC) proteins assemble to form channels for calcium and sodium ion entry.Intriguingly, whereas member 5 of the family (TRPC5) readily form
【作 者】
：
Bing Hou Sarka Tumova Mohamed S Amer David J Beech 
【机 构】
：
Multidisciplinary Cardiovascular Research Centre, Faculty of Biological Sciences, University of Leed
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
【关键词】
：
calcium-permeable channel non-selective cationic channel lipid raft cholesterol 
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The widely expressed Transient Receptor Potential Canonical (TRPC) proteins assemble to form channels for calcium and sodium ion entry.Intriguingly, whereas member 5 of the family (TRPC5) readily forms functional homomeric channels,member 1 (TRPC1) forms channels poorly or not at all.TRPC1, however, readily forms heteromers with TRPC5 but the purpose of its involvement is incompletely understood.
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