Effects of replacing a phosphorylation site with glutamate on the biological characteristics of huma

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Raf kinase inhibitor protein (RKIP), belonging to the PEBP family, plays a pivotal modulatory role in several protein kinase signaling cascades.RKIP cross-modulates MAPK and GPCR pathways by phosphorylation at its serine 153 site,which leads to the release of RKIP from Raf1, and binding with GRK2.
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