The analysis of host-based gene expression shows a great potential on the early diagnosis of infectious diseases,especially for influenza prediction.We have developed a novel edge-based network,i.e.edge-network,to detect early signals of diseases (i.e.influenza) on transcriptome by identifying the edge-biomarkers quantified with warning score from dynamical network biomarkers[1].Specifically,we show that the stochastic network of a biological system can be described by the integration of its node-network and its edge-network in a more accurate manner than conventional methods.